CMap Candidate Details

Structure:
CMap ID: C12300
Pert ID: BRD-K31283835
Compound Name: tofacitinib
Targets: JAK1; JAK2; JAK3
MoA: JAK inhibitor
SMILES: C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N
InchiKey: UJLAWZDWDVHWOW-YPMHNXCESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
30417 BRD-K31283835 ASC 10 uM 24 h 0.19 0.81 0.0 0.31 1.1 0.69
31016 BRD-K31283835 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.7 0.03
31321 BRD-K31283835 HEPG2 10 uM 6 h -0.24 -1.0 0.14 -0.21 -0.71 0.04
31566 BRD-K31283835 HT29 10 uM 6 h -0.21 -0.86 0.01 0.0 0.0 0.0
32164 BRD-K31283835 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33000 BRD-K31283835 SKB 10 uM 24 h 0.31 1.28 0.64 0.0 0.0 0.0
33272 BRD-K31283835 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90611 BRD-K31283835 HCT116 0.04 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
90694 BRD-K31283835 MCF10A 0.04 uM 24 h -0.23 -0.96 0.1 0.24 0.84 0.13
95825 BRD-K31283835 A375 0.37 uM 6 h 0.0 0.0 0.0 -0.35 -1.19 1.15
95854 BRD-K31283835 NPC 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95917 BRD-K31283835 YAPC 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95953 BRD-K31283835 A549 0.37 uM 6 h 0.19 0.79 0.0 0.0 0.0 0.0
95965 BRD-K31283835 PC3 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97938 BRD-K31283835 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.78
97965 BRD-K31283835 P1A82 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97976 BRD-K31283835 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).