CMap Candidate Details

Structure:
CMap ID: C01231
Pert ID: BRD-A51410489
Compound Name: yohimbine
Targets: ADRA2A; ADRA2B; ADRA2C; HTR1A; HTR1B; HTR1D; HTR2B
MoA: Adrenergic receptor antagonist
SMILES: COC(=O)C1C(O)CCC2CN3CCc4c([nH]c5ccccc45)C3CC12
InchiKey: BLGXFZZNTVWLAY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2967 BRD-A51410489 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3107 BRD-A51410489 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3443 BRD-A51410489 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3926 BRD-A51410489 VCAP 10 uM 6 h 0.0 0.0 0.0 0.31 1.1 0.69
39050 BRD-A51410489 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39399 BRD-A51410489 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40182 BRD-A51410489 HT29 10 uM 6 h 0.22 0.91 0.03 -0.37 -1.24 1.32
40569 BRD-A51410489 MCF??7.00 10 uM 6 h -0.21 -0.86 0.01 -0.31 -1.06 0.72
100204 BRD-A51410489 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).