CMap Candidate Details

Structure:
CMap ID: C12311
Pert ID: BRD-K31309378
Compound Name: lucitanib
Targets: FGFR1; FGFR2; FLT1; FLT4; KDR
MoA: FGFR inhibitor; VEGFR inhibitor
SMILES: CNC(=O)c1cccc2cc(ccc12)Oc1ccnc2cc(OCC3(N)CC3)c(OC)cc12
InchiKey: CUDVHEFYRIWYQD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90858 BRD-K31309378 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120510 BRD-K31309378 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120543 BRD-K31309378 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120615 BRD-K31309378 HELA 10 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
120644 BRD-K31309378 HT29 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
120694 BRD-K31309378 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120747 BRD-K31309378 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120768 BRD-K31309378 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120800 BRD-K31309378 YAPC 10 uM 24 h -0.27 -1.14 0.42 0.22 0.79 0.07
129000 BRD-K31309378 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.18 -0.62 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).