CMap Candidate Details

Structure:
CMap ID: C12313
Pert ID: BRD-K31313613
Compound Name: BS-181
Targets: CDK7
MoA: CDK inhibitor
SMILES: CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12
InchiKey: DNYBIOICMDTDAP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92881 BRD-K31313613 A375 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
92909 BRD-K31313613 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92949 BRD-K31313613 ASC 10 uM 24 h 0.0 0.0 0.0 0.43 1.51 2.27
93021 BRD-K31313613 CD34 10 uM 24 h 0.36 1.5 1.43 0.0 0.0 0.0
93056 BRD-K31313613 HA1E 10 uM 24 h 0.34 1.43 1.12 0.0 0.0 0.0
93106 BRD-K31313613 HEK293 1.11 uM 24 h -0.32 -1.33 0.9 0.29 1.02 0.48
93146 BRD-K31313613 HELA 10 uM 24 h 0.21 0.86 0.01 0.28 0.99 0.4
93190 BRD-K31313613 HEPG2 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93247 BRD-K31313613 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93297 BRD-K31313613 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
93333 BRD-K31313613 MCF10A 10 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
93375 BRD-K31313613 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.73
93406 BRD-K31313613 NPC 3.33 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
93520 BRD-K31313613 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93561 BRD-K31313613 THP1 10 uM 24 h -0.18 -0.76 0.0 0.26 0.93 0.27
93601 BRD-K31313613 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96420 BRD-K31313613 PC3 10 uM 24 h -0.19 -0.78 0.0 0.39 1.37 2.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).