CMap Candidate Details

Structure:
CMap ID: C12340
Pert ID: BRD-K31385749
Compound Name: ivabradine
Targets: HCN4; HCN1; HCN3
MoA: HCN channel antagonist; Sodium channel blocker; Potassium channel blocker
SMILES: COc1cc2C[C@@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC
InchiKey: ACRHBAYQBXXRTO-NRFANRHFSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
120511 BRD-K31385749 A375 0.04 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.71
120544 BRD-K31385749 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120589 BRD-K31385749 HA1E 0.04 uM 24 h 0.19 0.79 0.0 0.32 1.14 0.86
120645 BRD-K31385749 HT29 0.04 uM 24 h 0.24 1.01 0.12 -0.26 -0.88 0.26
120695 BRD-K31385749 JURKAT 0.37 uM 24 h -0.17 -0.7 0.0 -0.25 -0.85 0.19
120801 BRD-K31385749 YAPC 0.04 uM 24 h -0.22 -0.9 0.04 -0.34 -1.15 1.07
129027 BRD-K31385749 HELA 0.08 uM 3 h 0.2 0.82 0.0 0.22 0.77 0.06
129047 BRD-K31385749 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.15
129075 BRD-K31385749 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).