CMap Candidate Details

Structure:
CMap ID: C12362
Pert ID: BRD-K31447894
Compound Name: pravastatin
Targets: HMGCR
MoA: HMGCR inhibitor
SMILES: CC[C@H](C)C(=O)O[C@@H]1C[C@H](O)C=C2C=C[C@H](C)[C@@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@@H]12
InchiKey: TUZYXOIXSAXUGO-QBHFJHEUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95716 BRD-K31447894 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
121902 BRD-K31447894 A375 0.04 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.18
121921 BRD-K31447894 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122016 BRD-K31447894 HT29 1.11 uM 24 h 0.29 1.21 0.45 -0.21 -0.71 0.03
122062 BRD-K31447894 HUVEC 0.04 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.51
122091 BRD-K31447894 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122171 BRD-K31447894 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122223 BRD-K31447894 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130238 BRD-K31447894 HA1E 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130262 BRD-K31447894 HEK293 0.08 uM 24 h 0.23 0.96 0.07 0.32 1.12 0.77
130297 BRD-K31447894 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130363 BRD-K31447894 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130435 BRD-K31447894 MCF??7.00 0.74 uM 24 h -0.27 -1.13 0.4 -0.3 -1.02 0.59
130457 BRD-K31447894 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130499 BRD-K31447894 THP1 0.03 uM 24 h 0.26 1.07 0.2 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).