CMap Candidate Details

Structure:
CMap ID: C12387
Pert ID: BRD-K31495718
Compound Name: AZD-7687
Targets: --
MoA: --
SMILES: Cc1nc(C)c(nc1C(N)=O)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1
InchiKey: YXFNPRHZMOGREC-SHTZXODSSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121905 BRD-K31495718 A375 0.04 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.13
122020 BRD-K31495718 HT29 3.33 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
122068 BRD-K31495718 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.36 2.02
122093 BRD-K31495718 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122118 BRD-K31495718 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130210 BRD-K31495718 A549 0.03 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
130241 BRD-K31495718 HA1E 0.08 uM 24 h 0.23 0.98 0.09 -0.29 -0.98 0.48
130265 BRD-K31495718 HEK293 0.25 uM 24 h 0.22 0.9 0.03 -0.32 -1.07 0.76
130302 BRD-K31495718 HELA 0.03 uM 24 h -0.23 -0.94 0.08 -0.33 -1.12 0.93
130369 BRD-K31495718 JURKAT 0.03 uM 24 h -0.33 -1.38 1.09 0.28 0.98 0.37
130459 BRD-K31495718 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130483 BRD-K31495718 PC3 0.01 uM 24 h -0.24 -1.0 0.15 -0.25 -0.84 0.18
130501 BRD-K31495718 THP1 0.08 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.73
130536 BRD-K31495718 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).