CMap Candidate Details

Structure:
CMap ID: C12391
Pert ID: BRD-K31519811
Compound Name: PF-02545920
Targets: PDE10A
MoA: Phosphodiesterase inhibitor
SMILES: Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
InchiKey: AZEXWHKOMMASPA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1468 BRD-K31519811 NPC 10 uM 24 h 0.25 1.06 0.19 0.0 0.0 0.0
96723 BRD-K31519811 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96772 BRD-K31519811 PC3 10 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
121922 BRD-K31519811 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121939 BRD-K31519811 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121966 BRD-K31519811 HEK293 10 uM 24 h 0.21 0.88 0.02 -0.25 -0.84 0.18
122018 BRD-K31519811 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122065 BRD-K31519811 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122092 BRD-K31519811 MCF10A 10 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
122116 BRD-K31519811 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.34 1.86
122149 BRD-K31519811 MDAMB231 10 uM 24 h -0.17 -0.69 0.0 0.35 1.24 1.26
122202 BRD-K31519811 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130299 BRD-K31519811 HELA 2.22 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
130366 BRD-K31519811 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130533 BRD-K31519811 YAPC 2.22 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).