CMap Candidate Details

Structure:
CMap ID: C12402
Pert ID: BRD-K31553034
Compound Name: zibotentan
Targets: EDNRA
MoA: Endothelin receptor antagonist
SMILES: COc1nc(C)cnc1NS(=O)(=O)c1cccnc1-c1ccc(cc1)-c1nnco1
InchiKey: FJHHZXWJVIEFGJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29828 BRD-K31553034 A375 10 uM 6 h -0.27 -1.14 0.42 0.0 0.0 0.0
30418 BRD-K31553034 ASC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.65
30726 BRD-K31553034 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31017 BRD-K31553034 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.18 1.14
31322 BRD-K31553034 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31653 BRD-K31553034 HT29 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.55
31859 BRD-K31553034 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32165 BRD-K31553034 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32402 BRD-K31553034 NPC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.65
32627 BRD-K31553034 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33001 BRD-K31553034 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33273 BRD-K31553034 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96131 BRD-K31553034 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).