CMap Candidate Details

Structure:
CMap ID: C01247
Pert ID: BRD-A52193669
Compound Name: withaferin-a
Targets: NAMPT; IKBKB
MoA: IKK inhibitor
SMILES: CC([C@H]1CC[C@@H]2[C@H]3C[C@H]4O[C@@]44[C@@H](O)C=CC(=O)[C@@]4(C)C3CC[C@@]12C)[C@@H]1CC(C)=C(CO)C(=O)O1
InchiKey: DBRXOUCRJQVYJQ-MZNHJNIISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33880 BRD-A52193669 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33994 BRD-A52193669 ASC 10 uM 24 h 0.21 0.86 0.01 -0.35 -1.18 1.14
34271 BRD-A52193669 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.17 1.12
34507 BRD-A52193669 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34777 BRD-A52193669 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35051 BRD-A52193669 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35492 BRD-A52193669 MCF??7.00 10 uM 6 h 0.27 1.11 0.25 -0.49 -1.65 15.65
35514 BRD-A52193669 NEU 10 uM 24 h 0.18 0.74 0.0 0.32 1.13 0.81
35688 BRD-A52193669 NPC 10 uM 24 h -0.2 -0.83 0.0 -0.31 -1.06 0.73
36151 BRD-A52193669 PHH 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
36446 BRD-A52193669 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36932 BRD-A52193669 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.5 -1.67 15.65
96756 BRD-A52193669 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96811 BRD-A52193669 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).