CMap Candidate Details

Structure:
CMap ID: C12498
Pert ID: BRD-K31812033
Compound Name: levobunolol
Targets: ADRB1; ADRB2
MoA: Adrenergic receptor antagonist
SMILES: CC(C)(C)NC[C@H](O)COc1cccc2C(=O)CCCc12
InchiKey: IXHBTMCLRNMKHZ-LBPRGKRZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
99834 BRD-K31812033 U2OS 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
120547 BRD-K31812033 A549 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
120591 BRD-K31812033 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120616 BRD-K31812033 HELA 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120648 BRD-K31812033 HT29 1.11 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.36
120698 BRD-K31812033 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120770 BRD-K31812033 PC3 1.11 uM 24 h 0.3 1.25 0.54 0.0 0.0 0.0
120804 BRD-K31812033 YAPC 1.11 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.73
128986 BRD-K31812033 A375 0.01 uM 24 h -0.23 -0.95 0.09 -0.36 -1.21 1.24
129049 BRD-K31812033 MCF??7.00 0.74 uM 24 h 0.23 0.97 0.08 -0.25 -0.85 0.2
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).