CMap Candidate Details

Structure:
CMap ID: C12549
Pert ID: BRD-K31920458
Compound Name: mestranol
Targets: ESR1
MoA: Estrogen receptor agonist
SMILES: COc1ccc2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]4(O)C#C)[C@@H]3CCc2c1
InchiKey: IMSSROKUHAOUJS-MJCUULBUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3173 BRD-K31920458 HCC515 10 uM 24 h 0.17 0.73 0.0 0.0 0.0 0.0
24761 BRD-K31920458 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25152 BRD-K31920458 PC3 10 uM 24 h 0.21 0.88 0.01 0.22 0.77 0.06
25353 BRD-K31920458 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44362 BRD-K31920458 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44560 BRD-K31920458 A549 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.49
44920 BRD-K31920458 ASC 10 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
45491 BRD-K31920458 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45802 BRD-K31920458 MCF??7.00 10 uM 6 h 0.23 0.95 0.06 -0.26 -0.88 0.24
46039 BRD-K31920458 NPC 10 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
46356 BRD-K31920458 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46674 BRD-K31920458 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99838 BRD-K31920458 U2OS 6.66 uM 6 h 0.0 0.0 0.0 0.27 0.95 0.31
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).