CMap Candidate Details

Structure:
CMap ID: C12654
Pert ID: BRD-K32218650
Compound Name: MBX-2982
Targets: GPR119
MoA: Glucose dependent insulinotropic receptor agonist
SMILES: CCc1cnc(nc1)N1CCC(CC1)c1nc(COc2ccc(cc2)-n2cnnn2)cs1
InchiKey: NFTMKHWBOINJGM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121904 BRD-K32218650 A375 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
121923 BRD-K32218650 A549 10 uM 24 h 0.23 0.96 0.07 -0.26 -0.89 0.27
121940 BRD-K32218650 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121968 BRD-K32218650 HEK293 10 uM 24 h -0.26 -1.1 0.35 0.0 0.0 0.0
122019 BRD-K32218650 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122067 BRD-K32218650 HUVEC 10 uM 24 h -0.25 -1.05 0.23 0.0 0.0 0.0
122117 BRD-K32218650 MCF??7.00 10 uM 24 h -0.2 -0.85 0.01 -0.4 -1.36 2.02
122150 BRD-K32218650 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
122172 BRD-K32218650 PC3 10 uM 24 h 0.21 0.9 0.02 0.0 0.0 0.0
122203 BRD-K32218650 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130301 BRD-K32218650 HELA 0.01 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
130368 BRD-K32218650 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
130412 BRD-K32218650 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
130535 BRD-K32218650 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).