CMap Candidate Details

Structure:
CMap ID: C12676
Pert ID: BRD-K32285926
Compound Name: AMG-208
Targets: MET
MoA: Tyrosine kinase inhibitor
SMILES: COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccccc3)ccnc2c1
InchiKey: HEAIZQNMNCHNFD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
120518 BRD-K32285926 A375 10 uM 24 h 0.22 0.9 0.02 0.24 0.84 0.13
120553 BRD-K32285926 A549 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.71 0.04
120593 BRD-K32285926 HA1E 3.33 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
120617 BRD-K32285926 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120653 BRD-K32285926 HT29 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
120704 BRD-K32285926 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120775 BRD-K32285926 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120810 BRD-K32285926 YAPC 0.125 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
129053 BRD-K32285926 MCF??7.00 0.74 uM 24 h -0.37 -1.52 1.43 -0.25 -0.86 0.21
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).