CMap Candidate Details

Structure:
CMap ID: C12678
Pert ID: BRD-K32292990
Compound Name: CGP-53353
Targets: EGFR
MoA: PKC inhibitor; EGFR inhibitor
SMILES: Fc1ccc(Nc2cc3C(=O)NC(=O)c3cc2Nc2ccc(F)cc2)cc1
InchiKey: RONQPWQYDRPRGG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2862 BRD-K32292990 HA1E 10 uM 24 h -0.22 -0.9 0.04 -0.44 -1.48 15.35
3174 BRD-K32292990 HCC515 10 uM 24 h -0.23 -0.97 0.1 0.28 1.01 0.44
3482 BRD-K32292990 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3951 BRD-K32292990 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.6
44364 BRD-K32292990 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44561 BRD-K32292990 A549 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
44923 BRD-K32292990 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45493 BRD-K32292990 HT29 10 uM 6 h 0.19 0.8 0.0 0.44 1.56 2.33
45681 BRD-K32292990 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
46041 BRD-K32292990 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46677 BRD-K32292990 SKB 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
53442 BRD-K32292990 HEPG2 10 uM 6 h -0.25 -1.03 0.2 0.0 0.0 0.0
53574 BRD-K32292990 HUH7 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.17 1.12
53652 BRD-K32292990 PHH 2.5 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).