CMap Candidate Details

Structure:
CMap ID: C12708
Pert ID: BRD-K32398298
Compound Name: alprazolam
Targets: GABRA1; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ
MoA: Benzodiazepine receptor agonist
SMILES: Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12
InchiKey: VREFGVBLTWBCJP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24428 BRD-K32398298 A375 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.78 0.09
24665 BRD-K32398298 A549 10 uM 6 h -0.22 -0.93 0.07 0.31 1.11 0.72
24763 BRD-K32398298 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24894 BRD-K32398298 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25093 BRD-K32398298 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.2 1.21
25244 BRD-K32398298 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25355 BRD-K32398298 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).