CMap Candidate Details

Structure:
CMap ID: C01273
Pert ID: BRD-A53077924
Compound Name: tianeptine
Targets: OPRD1; OPRK1; OPRM1; SLC6A4
MoA: Selective serotonin reuptake enhancer
SMILES: CN1c2ccccc2C(NCCCCCCC(O)=O)c2ccc(Cl)cc2S1(=O)=O
InchiKey: JICJBGPOMZQUBB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1442 BRD-A53077924 NPC 8 uM 24 h -0.24 -0.99 0.13 0.0 0.0 0.0
6843 BRD-A53077924 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7086 BRD-A53077924 A549 10 uM 6 h 0.0 0.0 0.0 0.23 0.82 0.1
7238 BRD-A53077924 HA1E 10 uM 24 h 0.2 0.82 0.0 -0.24 -0.81 0.13
7556 BRD-A53077924 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7956 BRD-A53077924 HT29 10 uM 6 h -0.29 -1.2 0.57 0.0 0.0 0.0
8245 BRD-A53077924 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.39 -1.31 1.71
8454 BRD-A53077924 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8589 BRD-A53077924 VCAP 10 uM 24 h 0.28 1.16 0.34 0.0 0.0 0.0
100212 BRD-A53077924 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.71 0.04
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).