CMap Candidate Details

Structure:
CMap ID: C12759
Pert ID: BRD-K32536677
Compound Name: AGK-2
Targets: SIRT2
MoA: SIRT inhibitor
SMILES: Clc1ccc(Cl)c(c1)c2ccc(/C=C(C#N)/C(=O)Nc3cccc4ncccc34)o2
InchiKey: SVENPFFEMUOOGK-SDNWHVSQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9409 BRD-K32536677 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9717 BRD-K32536677 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10504 BRD-K32536677 HCT116 10 uM 6 h 0.18 0.76 0.0 0.25 0.88 0.18
11471 BRD-K32536677 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11751 BRD-K32536677 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12035 BRD-K32536677 NCIH596 10 uM 6 h -0.19 -0.8 0.0 0.0 0.0 0.0
12778 BRD-K32536677 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13259 BRD-K32536677 U937 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.22 1.24
13613 BRD-K32536677 VCAP 10 uM 6 h 0.2 0.83 0.0 -0.22 -0.75 0.07
93611 BRD-K32536677 A549 3.33 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
93646 BRD-K32536677 ASC 1.11 uM 24 h 0.21 0.9 0.02 0.0 0.0 0.0
93704 BRD-K32536677 CD34 10 uM 24 h 0.44 1.85 2.03 0.27 0.97 0.35
93832 BRD-K32536677 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93879 BRD-K32536677 HELA 0.12 uM 24 h -0.24 -1.02 0.18 -0.25 -0.84 0.17
93919 BRD-K32536677 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93956 BRD-K32536677 HUVEC 1.11 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
94016 BRD-K32536677 JURKAT 0.12 uM 24 h 0.36 1.51 1.44 0.0 0.0 0.0
94056 BRD-K32536677 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.73
94096 BRD-K32536677 NEU 0.04 uM 24 h -0.23 -0.98 0.12 0.0 0.0 0.0
94156 BRD-K32536677 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94229 BRD-K32536677 SHSY5Y 0.04 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
94280 BRD-K32536677 SKL 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94330 BRD-K32536677 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94375 BRD-K32536677 YAPC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96918 BRD-K32536677 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117005 BRD-K32536677 A375 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
117085 BRD-K32536677 HA1E 0.125 uM 24 h -0.27 -1.11 0.37 0.23 0.83 0.11
117120 BRD-K32536677 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117216 BRD-K32536677 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).