CMap Candidate Details

Structure:
CMap ID: C01277
Pert ID: BRD-A53176877
Compound Name: methylprednisolone
Targets: NR3C1
MoA: Glucocorticoid receptor agonist
SMILES: C[C@H]1CC2C3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)C2[C@@]2(C)C=CC(=O)C=C12
InchiKey: VHRSUDSXCMQTMA-IETLARDKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124274 BRD-A53176877 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124383 BRD-A53176877 HT29 10 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
124416 BRD-A53176877 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124517 BRD-A53176877 PC3 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124545 BRD-A53176877 YAPC 0.125 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.28
132357 BRD-A53176877 A549 2.22 uM 24 h -0.27 -1.11 0.37 0.0 0.0 0.0
132388 BRD-A53176877 HA1E 0.08 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.36
132422 BRD-A53176877 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132443 BRD-A53176877 HELA 0.08 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
132493 BRD-A53176877 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.39
132521 BRD-A53176877 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
132552 BRD-A53176877 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
132603 BRD-A53176877 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).