CMap Candidate Details

Structure:
CMap ID: C12819
Pert ID: BRD-K32744045
Compound Name: disulfiram
Targets: ALDH2
MoA: TRPV agonist; DNA methyltransferase inhibitor; Aldehyde dehydrogenase inhibitor
SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC
InchiKey: AUZONCFQVSMFAP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24666 BRD-K32744045 A549 10 uM 6 h -0.26 -1.07 0.28 -0.44 -1.46 15.35
24764 BRD-K32744045 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24895 BRD-K32744045 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25501 BRD-K32744045 VCAP 10 uM 6 h -0.26 -1.07 0.27 0.0 0.0 0.0
51276 BRD-K32744045 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
52858 BRD-K32744045 HEPG2 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53188 BRD-K32744045 MCF10A 30 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91244 BRD-K32744045 HUH7 12 uM 72 h -0.31 -1.31 0.82 -0.27 -0.89 0.27
96551 BRD-K32744045 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97171 BRD-K32744045 A375 1.11 uM 24 h 0.0 0.0 0.0 -0.45 -1.51 15.35
99848 BRD-K32744045 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
120633 BRD-K32744045 HELA 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
120706 BRD-K32744045 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120812 BRD-K32744045 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136400 BRD-K32744045 SHSY5Y 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).