CMap Candidate Details
Structure:
| CMap ID: | C12849 |
| Pert ID: | BRD-K32842773 |
| Compound Name: | pemetrexed |
| Targets: | DHFR; GART; TYMS |
| MoA: | Thymidylate synthase inhibitor; Dihydrofolate reductase inhibitor |
| SMILES: | Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c[nH]c2[nH]1 |
| InchiKey: | WBXPDJSOTKVWSJ-ZDUSSCGKSA-N |
| Compound Aliases: | -- |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 95494 | BRD-K32842773 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 95589 | BRD-K32842773 | MCF??7.00 | 1.11 uM | 48 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 95683 | BRD-K32842773 | U2OS | 1.11 uM | 48 h | 0.0 | 0.0 | 0.0 | -0.41 | -1.38 | 2.02 |