CMap Candidate Details

Structure:
CMap ID: C01289
Pert ID: BRD-A54029483
Compound Name: IRL-2500
Targets: EDNRB
MoA: Endothelin receptor antagonist
SMILES: CN(C(Cc1ccc(cc1)c2ccccc2)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)O)C(=O)c5cc(C)cc(C)c5
InchiKey: UZDORQWMYRRLQV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1502 BRD-A54029483 HA1E 10 uM 24 h 0.24 1.01 0.11 0.24 0.85 0.14
1833 BRD-A54029483 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2343 BRD-A54029483 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2463 BRD-A54029483 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41677 BRD-A54029483 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42019 BRD-A54029483 A549 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.81 0.13
42217 BRD-A54029483 ASC 10 uM 24 h -0.27 -1.11 0.37 0.28 0.99 0.39
42559 BRD-A54029483 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42867 BRD-A54029483 HT29 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.25
43129 BRD-A54029483 MCF??7.00 10 uM 24 h -0.25 -1.05 0.24 0.0 0.0 0.0
43418 BRD-A54029483 NPC 10 uM 24 h 0.29 1.19 0.42 0.0 0.0 0.0
43728 BRD-A54029483 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100217 BRD-A54029483 U2OS 10 uM 6 h 0.25 1.04 0.15 0.21 0.74 0.04
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).