CMap Candidate Details

Structure:
CMap ID: C12936
Pert ID: BRD-K33127281
Compound Name: adapalene
Targets: RARA; RARB; RARG
MoA: Retinoid receptor agonist
SMILES: COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
InchiKey: LZCDAPDGXCYOEH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
98889 BRD-K33127281 NEU 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
99141 BRD-K33127281 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121928 BRD-K33127281 A549 10 uM 24 h 0.18 0.75 0.0 0.28 0.99 0.4
121942 BRD-K33127281 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121970 BRD-K33127281 HEK293 10 uM 24 h 0.2 0.83 0.0 -0.26 -0.86 0.22
121993 BRD-K33127281 HELA 3.33 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
122023 BRD-K33127281 HT29 3.33 uM 24 h -0.17 -0.73 0.0 0.29 1.02 0.47
122075 BRD-K33127281 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122094 BRD-K33127281 MCF10A 10 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
122124 BRD-K33127281 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 -0.4 -1.34 1.85
122151 BRD-K33127281 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122176 BRD-K33127281 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130190 BRD-K33127281 A375 2.22 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.71
130376 BRD-K33127281 JURKAT 0.01 uM 24 h -0.33 -1.38 1.08 0.21 0.73 0.03
130507 BRD-K33127281 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130540 BRD-K33127281 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).