CMap Candidate Details

Structure:
CMap ID: C12965
Pert ID: BRD-K33226500
Compound Name: indinavir
Targets: CYP3A7; CYP3A4; CYP3A5
MoA: HIV protease inhibitor
SMILES: CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12
InchiKey: CBVCZFGXHXORBI-PXQQMZJSSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1235 BRD-K33226500 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1370 BRD-K33226500 U2OS 0.12 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
25016 BRD-K33226500 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
25502 BRD-K33226500 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96635 BRD-K33226500 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96700 BRD-K33226500 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.19 -0.63 0.01
120659 BRD-K33226500 HT29 0.04 uM 24 h -0.23 -0.96 0.1 0.0 0.0 0.0
120712 BRD-K33226500 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120820 BRD-K33226500 YAPC 1.11 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
129005 BRD-K33226500 HA1E 0.25 uM 24 h -0.21 -0.87 0.02 0.24 0.85 0.15
129020 BRD-K33226500 HELA 0.74 uM 24 h 0.29 1.2 0.42 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).