CMap Candidate Details

Structure:
CMap ID: C13077
Pert ID: BRD-K33610132
Compound Name: rociletinib
Targets: EGFR
MoA: EGFR inhibitor
SMILES: COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
InchiKey: HUFOZJXAKZVRNJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
88001 BRD-K33610132 A549 8 uM 24 h -0.22 -0.93 0.07 -0.26 -0.89 0.27
88046 BRD-K33610132 MCF??7.00 6.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121909 BRD-K33610132 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121971 BRD-K33610132 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
121994 BRD-K33610132 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122024 BRD-K33610132 HT29 10 uM 24 h -0.25 -1.03 0.2 -0.26 -0.86 0.21
122076 BRD-K33610132 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.51
122095 BRD-K33610132 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122152 BRD-K33610132 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122177 BRD-K33610132 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122205 BRD-K33610132 THP1 10 uM 24 h -0.26 -1.07 0.28 0.0 0.0 0.0
122227 BRD-K33610132 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
130245 BRD-K33610132 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.24
130377 BRD-K33610132 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).