CMap Candidate Details

Structure:
CMap ID: C01308
Pert ID: BRD-A54880345
Compound Name: etomidate
Targets: GABRA1; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ
MoA: GABA receptor modulator; Membrane integrity inhibitor; Membrane permeability inhibitor
SMILES: CCOC(=O)c1cncn1C(C)c1ccccc1
InchiKey: NPUKDXXFDDZOKR-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6405 BRD-A54880345 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37517 BRD-A54880345 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37831 BRD-A54880345 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38366 BRD-A54880345 NPC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.14
50300 BRD-A54880345 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.01 0.57
124330 BRD-A54880345 HEK293 10 uM 24 h 0.18 0.74 0.0 0.22 0.79 0.08
124369 BRD-A54880345 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.79
124438 BRD-A54880345 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124499 BRD-A54880345 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
124562 BRD-A54880345 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132342 BRD-A54880345 A375 0.01 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.97
132371 BRD-A54880345 A549 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132401 BRD-A54880345 HA1E 0.74 uM 24 h 0.25 1.03 0.13 -0.24 -0.82 0.15
132473 BRD-A54880345 HT29 0.74 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
132509 BRD-A54880345 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
132537 BRD-A54880345 MCF??7.00 0.25 uM 24 h 0.23 0.95 0.07 0.24 0.84 0.12
132577 BRD-A54880345 PC3 2.22 uM 24 h 0.21 0.88 0.01 0.0 0.0 0.0
132627 BRD-A54880345 THP1 2.22 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).