CMap Candidate Details

Structure:
CMap ID: C13134
Pert ID: BRD-K33818169
Compound Name: GW-3965
Targets: NR1H3; NR1H2
MoA: LXR agonist; ABC transporter expression enhancer
SMILES: OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c2ccccc2)Cc2cccc(c2Cl)C(F)(F)F)c1
InchiKey: NAXSRXHZFIBFMI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5444 BRD-K33818169 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5612 BRD-K33818169 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6017 BRD-K33818169 HT29 10 uM 6 h 0.0 0.0 0.0 0.32 1.13 0.8
6180 BRD-K33818169 PC3 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.78
6437 BRD-K33818169 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.17
37143 BRD-K33818169 A375 10 uM 6 h 0.21 0.86 0.01 0.25 0.89 0.2
37280 BRD-K33818169 A549 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.18
37636 BRD-K33818169 ASC 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.69
37894 BRD-K33818169 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38197 BRD-K33818169 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38462 BRD-K33818169 NPC 10 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.22
38942 BRD-K33818169 SKB 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.13
99859 BRD-K33818169 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.07 0.77
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).