CMap Candidate Details

Structure:
CMap ID: C13192
Pert ID: BRD-K34008116
Compound Name: dolasetron
Targets: HTR3A
MoA: Serotonin receptor antagonist
SMILES: O=C(O[C@H]1C[C@@H]2C[C@@H]3C[C@@H](C1)N2CC3=O)c1c[nH]c2ccccc12
InchiKey: UKTAZPQNNNJVKR-XDQVBPFNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121790 BRD-K34008116 HT29 0.37 uM 24 h -0.26 -1.09 0.32 -0.17 -0.59 0.0
121839 BRD-K34008116 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.93
121867 BRD-K34008116 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129752 BRD-K34008116 A375 0.74 uM 24 h -0.29 -1.19 0.53 0.0 0.0 0.0
129786 BRD-K34008116 HA1E 0.01 uM 24 h 0.3 1.25 0.56 0.0 0.0 0.0
129820 BRD-K34008116 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.21 0.76 0.05
129869 BRD-K34008116 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129913 BRD-K34008116 JURKAT 0.01 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
129947 BRD-K34008116 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
129994 BRD-K34008116 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130031 BRD-K34008116 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.5
130103 BRD-K34008116 THP1 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).