CMap Candidate Details

Structure:
CMap ID: C13222
Pert ID: BRD-K34098590
Compound Name: tienilic-acid
Targets: CYP2C9; SLC12A1
MoA: Sodium/potassium/chloride transporter inhibitor
SMILES: OC(=O)COc1ccc(C(=O)c2cccs2)c(Cl)c1Cl
InchiKey: AGHANLSBXUWXTB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
49830 BRD-K34098590 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50000 BRD-K34098590 A549 10 uM 6 h -0.18 -0.77 0.0 -0.32 -1.09 0.82
50175 BRD-K34098590 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50352 BRD-K34098590 HCC515 10 uM 6 h 0.0 0.0 0.0 0.23 0.8 0.08
50523 BRD-K34098590 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50746 BRD-K34098590 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.26
50834 BRD-K34098590 PC3 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
51143 BRD-K34098590 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).