CMap Candidate Details
Structure:
| CMap ID: | C01323 |
| Pert ID: | BRD-A55424491 |
| Compound Name: | methotrexate |
| Targets: | DHFR |
| MoA: | Dihydrofolate reductase inhibitor |
| SMILES: | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O |
| InchiKey: | FBOZXECLQNJBKD-UHFFFAOYSA-N |
| Compound Aliases: | methrotrexate |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 51402 | BRD-A55424491 | PC3 | 10 uM | 24 h | 0.27 | 1.13 | 0.3 | -0.31 | -1.05 | 0.72 |
| 52381 | BRD-A55424491 | HA1E | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.31 | 1.71 |
| 90765 | BRD-A55424491 | HPTEC | 10 uM | 24 h | 0.24 | 0.99 | 0.1 | 0.0 | 0.0 | 0.0 |
| 97506 | BRD-A55424491 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 97605 | BRD-A55424491 | NKDBA | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.26 | -0.89 | 0.26 |
| 100227 | BRD-A55424491 | U2OS | 10 uM | 6 h | -0.21 | -0.86 | 0.02 | 0.0 | 0.0 | 0.0 |