CMap Candidate Details

Structure:
CMap ID: C13242
Pert ID: BRD-K34185671
Compound Name: AMG-517
Targets: TRPV1
MoA: TRPV antagonist
SMILES: CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1
InchiKey: YUTIXVXZQIQWGY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121912 BRD-K34185671 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121929 BRD-K34185671 A549 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121945 BRD-K34185671 HA1E 10 uM 24 h 0.17 0.69 0.0 0.0 0.0 0.0
122081 BRD-K34185671 HUVEC 1.11 uM 24 h -0.18 -0.73 0.0 0.3 1.07 0.63
122154 BRD-K34185671 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122180 BRD-K34185671 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122206 BRD-K34185671 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130272 BRD-K34185671 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130308 BRD-K34185671 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
130330 BRD-K34185671 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130381 BRD-K34185671 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130421 BRD-K34185671 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.29
130440 BRD-K34185671 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130543 BRD-K34185671 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).