CMap Candidate Details

Structure:
CMap ID: C01331
Pert ID: BRD-A55579717
Compound Name: cytisine
Targets: CHRNA2; CHRNA3; CHRNA4; CHRNA7; CHRNB2
MoA: Acetylcholine receptor agonist
SMILES: O=c1cccc2C3CNC[C@@H](C3)Cn12
InchiKey: ANJTVLIZGCUXLD-VEDVMXKPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
100228 BRD-A55579717 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123782 BRD-A55579717 A375 1.11 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
123823 BRD-A55579717 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123880 BRD-A55579717 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123933 BRD-A55579717 HELA 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 1.01
123979 BRD-A55579717 JURKAT 1.11 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
124035 BRD-A55579717 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124112 BRD-A55579717 MDAMB231 0.04 uM 24 h -0.23 -0.95 0.09 -0.23 -0.77 0.08
124162 BRD-A55579717 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.34
124215 BRD-A55579717 YAPC 0.04 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
132156 BRD-A55579717 HA1E 0.01 uM 24 h 0.3 1.23 0.5 0.0 0.0 0.0
132215 BRD-A55579717 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132247 BRD-A55579717 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132283 BRD-A55579717 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136427 BRD-A55579717 SHSY5Y 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).