CMap Candidate Details

Structure:
CMap ID: C01332
Pert ID: BRD-A55594068
Compound Name: vinblastine
Targets: TUBB
MoA: Tubulin inhibitor; Microtubule inhibitor
SMILES: CC[C@]1(O)CC2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
InchiKey: JXLYSJRDGCGARV-CUGARIAGSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4022 BRD-A55594068 HA1E 10 uM 24 h 0.0 0.0 0.0 0.33 1.15 0.9
4312 BRD-A55594068 HCC515 10 uM 24 h -0.22 -0.94 0.07 -0.37 -1.24 1.31
4621 BRD-A55594068 PC3 10 uM 24 h -0.26 -1.09 0.32 -0.46 -1.56 15.65
5003 BRD-A55594068 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37087 BRD-A55594068 A375 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.96 0.44
37348 BRD-A55594068 A549 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.34 1.85
37520 BRD-A55594068 ASC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
37832 BRD-A55594068 HEPG2 10 uM 6 h 0.22 0.9 0.02 0.0 0.0 0.0
38025 BRD-A55594068 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38157 BRD-A55594068 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38369 BRD-A55594068 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38873 BRD-A55594068 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).