CMap Candidate Details

Structure:
CMap ID: C13379
Pert ID: BRD-K34581968
Compound Name: BMS-536924
Targets: IGF1R
MoA: IGF-1 inhibitor
SMILES: Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1
InchiKey: FDBVBFZVZLTNFJ-KKPVDXMRSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9065 BRD-K34581968 A375 12 uM 6 h 0.22 0.94 0.06 0.0 0.0 0.0
9719 BRD-K34581968 H1299 12 uM 6 h 0.0 0.0 0.0 0.34 1.22 1.15
9994 BRD-K34581968 HA1E 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10507 BRD-K34581968 HCT116 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11122 BRD-K34581968 HT29 12 uM 6 h -0.17 -0.69 0.0 0.31 1.11 0.72
11278 BRD-K34581968 MCF??7.00 12 uM 6 h 0.0 0.0 0.0 -0.31 -1.05 0.7
11474 BRD-K34581968 NCIH2073 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11754 BRD-K34581968 NCIH508 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12038 BRD-K34581968 NCIH596 12 uM 6 h 0.0 0.0 0.0 0.32 1.12 0.74
12304 BRD-K34581968 NOMO1 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12781 BRD-K34581968 SW480 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13118 BRD-K34581968 THP1 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13262 BRD-K34581968 U937 12 uM 6 h 0.0 0.0 0.0 0.24 0.87 0.17
13614 BRD-K34581968 VCAP 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
118103 BRD-K34581968 A549 1.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118191 BRD-K34581968 HCC515 0.37 uM 24 h 0.22 0.91 0.04 0.0 0.0 0.0
118241 BRD-K34581968 HEPG2 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118366 BRD-K34581968 PC3 1.25 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.11
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).