CMap Candidate Details

Structure:
CMap ID: C13433
Pert ID: BRD-K34776109
Compound Name: glimepiride
Targets: KCNJ11; ABCC8
MoA: Insulin secretagogue
SMILES: CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]2CC[C@H](C)CC2)C1=O
InchiKey: WIGIZIANZCJQQY-RUCARUNLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4419 BRD-K34776109 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5077 BRD-K34776109 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.06 0.75
37640 BRD-K34776109 ASC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
38466 BRD-K34776109 NPC 10 uM 24 h 0.29 1.21 0.46 0.0 0.0 0.0
38712 BRD-K34776109 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91401 BRD-K34776109 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
96426 BRD-K34776109 PC3 10 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.52
120529 BRD-K34776109 A375 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
120566 BRD-K34776109 A549 1.11 uM 24 h 0.33 1.36 0.97 0.0 0.0 0.0
120605 BRD-K34776109 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.22
120671 BRD-K34776109 HT29 10 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
120724 BRD-K34776109 JURKAT 10 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
120832 BRD-K34776109 YAPC 3.33 uM 24 h 0.21 0.88 0.02 0.0 0.0 0.0
129038 BRD-K34776109 HELA 0.03 uM 3 h 0.0 0.0 0.0 -0.27 -0.92 0.32
129059 BRD-K34776109 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).