CMap Candidate Details

Structure:
CMap ID: C01344
Pert ID: BRD-A56020723
Compound Name: CA-074-Me
Targets: CTSB
MoA: Cathepsin inhibitor
SMILES: CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)N2CCC[C@H]2C(=O)OC
InchiKey: XGWSRLSPWIEMLQ-RQLZCWDZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6847 BRD-A56020723 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7091 BRD-A56020723 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7400 BRD-A56020723 HA1E 10 uM 6 h 0.36 1.48 1.12 0.23 0.83 0.11
7563 BRD-A56020723 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7784 BRD-A56020723 HT29 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
8051 BRD-A56020723 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8313 BRD-A56020723 PC3 10 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
8596 BRD-A56020723 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100231 BRD-A56020723 U2OS 12.5 uM 6 h -0.2 -0.83 0.0 -0.36 -1.2 1.2
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).