CMap Candidate Details

Structure:
CMap ID: C01349
Pert ID: BRD-A56359832
Compound Name: zileuton
Targets: ALOX5
MoA: Leukotriene inhibitor; Lipoxygenase inhibitor
SMILES: CC(N(O)C(N)=O)c1cc2ccccc2s1
InchiKey: MWLSOWXNZPKENC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9597 BRD-A56359832 H1299 150 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10188 BRD-A56359832 HCC515 150 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.12
10405 BRD-A56359832 HCT116 150 uM 6 h 0.0 0.0 0.0 -0.25 -0.84 0.18
10672 BRD-A56359832 HEPG2 150 uM 6 h 0.0 0.0 0.0 -0.22 -0.76 0.07
11658 BRD-A56359832 NCIH508 150 uM 6 h 0.0 0.0 0.0 -0.37 -1.23 1.28
11919 BRD-A56359832 NCIH596 150 uM 6 h 0.0 0.0 0.0 -0.21 -0.71 0.03
13153 BRD-A56359832 U937 150 uM 6 h 0.22 0.91 0.04 -0.39 -1.31 1.7
24536 BRD-A56359832 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24990 BRD-A56359832 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25300 BRD-A56359832 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91074 BRD-A56359832 HUH7 15 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
121574 BRD-A56359832 A375 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
121620 BRD-A56359832 HA1E 3.33 uM 24 h -0.19 -0.79 0.0 0.36 1.28 1.37
121651 BRD-A56359832 HELA 0.04 uM 24 h 0.21 0.88 0.02 0.24 0.85 0.14
121667 BRD-A56359832 HT29 0.125 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.06
121714 BRD-A56359832 YAPC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129706 BRD-A56359832 PC3 0.08 uM 24 h -0.3 -1.24 0.64 -0.25 -0.85 0.19
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).