CMap Candidate Details

Structure:
CMap ID: C01350
Pert ID: BRD-A56371469
Compound Name: AGI-5198
Targets: IDH1
MoA: Isocitrate dehydrogenase inhibitor
SMILES: Cc1nccn1CC(=O)N(C(C(=O)NC1CCCCC1)c1ccccc1C)c1cccc(F)c1
InchiKey: FNYGWXSATBUBER-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123519 BRD-A56371469 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123541 BRD-A56371469 HA1E 3.33 uM 24 h -0.22 -0.91 0.05 0.39 1.38 2.17
123579 BRD-A56371469 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123654 BRD-A56371469 HT29 3.33 uM 24 h -0.28 -1.15 0.44 -0.19 -0.65 0.01
123696 BRD-A56371469 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
123768 BRD-A56371469 YAPC 10 uM 24 h 0.19 0.81 0.0 -0.28 -0.95 0.4
132041 BRD-A56371469 HELA 0.74 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.66
132087 BRD-A56371469 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132118 BRD-A56371469 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.19 -0.66 0.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).