CMap Candidate Details

Structure:
CMap ID: C01355
Pert ID: BRD-A56592690
Compound Name: PX-12
Targets: TXN; TXNRD1
MoA: Thioredoxin inhibitor
SMILES: CCC(C)SSc1ncc[nH]1
InchiKey: BPBPYQWMFCTCNG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9146 BRD-A56592690 A549 30 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.61
9295 BRD-A56592690 AGS 30 uM 6 h 0.0 0.0 0.0 -0.33 -1.12 0.94
9598 BRD-A56592690 H1299 30 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10369 BRD-A56592690 HCC515 30 uM 6 h -0.26 -1.09 0.31 0.0 0.0 0.0
10406 BRD-A56592690 HCT116 30 uM 6 h 0.0 0.0 0.0 0.29 1.04 0.55
10673 BRD-A56592690 HEPG2 30 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11249 BRD-A56592690 MCF??7.00 30 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11346 BRD-A56592690 NCIH2073 30 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11659 BRD-A56592690 NCIH508 30 uM 6 h 0.28 1.18 0.39 0.0 0.0 0.0
12209 BRD-A56592690 NOMO1 30 uM 6 h -0.23 -0.96 0.1 0.0 0.0 0.0
12671 BRD-A56592690 SW480 30 uM 6 h 0.0 0.0 0.0 0.26 0.93 0.26
13113 BRD-A56592690 THP1 30 uM 6 h 0.0 0.0 0.0 -0.39 -1.31 1.71
13154 BRD-A56592690 U937 30 uM 6 h 0.0 0.0 0.0 -0.42 -1.42 2.02
13425 BRD-A56592690 VCAP 30 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
96257 BRD-A56592690 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123531 BRD-A56592690 HA1E 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.74
123557 BRD-A56592690 HEK293 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
123676 BRD-A56592690 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.24
131971 BRD-A56592690 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132029 BRD-A56592690 HELA 2.22 uM 24 h 0.31 1.29 0.64 0.25 0.88 0.19
132056 BRD-A56592690 HT29 2.22 uM 24 h -0.23 -0.98 0.12 0.0 0.0 0.0
132102 BRD-A56592690 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132131 BRD-A56592690 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.24 0.87 0.17
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).