CMap Candidate Details

Structure:
CMap ID: C13551
Pert ID: BRD-K35169477
Compound Name: taranabant
Targets: CNR1
MoA: Cannabinoid receptor inverse agonist
SMILES: C[C@H](NC(=O)C(C)(C)Oc1ccc(cn1)C(F)(F)F)[C@@H](Cc1ccc(Cl)cc1)c1cccc(c1)C#N
InchiKey: QLYKJCMUNUWAGO-GAJHUEQPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96493 BRD-K35169477 A375 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
96561 BRD-K35169477 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121930 BRD-K35169477 A549 0.04 uM 24 h -0.28 -1.18 0.5 -0.25 -0.85 0.2
121947 BRD-K35169477 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121996 BRD-K35169477 HELA 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122029 BRD-K35169477 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122084 BRD-K35169477 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
122129 BRD-K35169477 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122208 BRD-K35169477 THP1 0.04 uM 24 h -0.27 -1.13 0.41 0.23 0.83 0.11
122230 BRD-K35169477 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130275 BRD-K35169477 HEK293 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130384 BRD-K35169477 JURKAT 0.74 uM 24 h 0.22 0.93 0.04 0.31 1.11 0.72
130424 BRD-K35169477 MCF10A 0.01 uM 24 h -0.26 -1.09 0.33 0.28 0.98 0.38
130470 BRD-K35169477 MDAMB231 0.01 uM 24 h -0.23 -0.96 0.09 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).