CMap Candidate Details

Structure:
CMap ID: C13652
Pert ID: BRD-K35498378
Compound Name: alrestatin
Targets: AKR1B1
MoA: Aldose reductase inhibitor
SMILES: OC(=O)CN1C(=O)c2cccc3cccc(C1=O)c23
InchiKey: GCUCIFQCGJIRNT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5202 BRD-K35498378 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5445 BRD-K35498378 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5613 BRD-K35498378 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6019 BRD-K35498378 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6273 BRD-K35498378 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6356 BRD-K35498378 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39446 BRD-K35498378 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39679 BRD-K35498378 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39992 BRD-K35498378 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40465 BRD-K35498378 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.34
41101 BRD-K35498378 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41434 BRD-K35498378 SKB 10 uM 24 h 0.22 0.93 0.05 0.29 1.01 0.45
99875 BRD-K35498378 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).