CMap Candidate Details

Structure:
CMap ID: C13677
Pert ID: BRD-K35586044
Compound Name: yohimbine
Targets: ADRA2A; ADRA2B; ADRA2C; HTR1A; HTR1B; HTR1D; HTR2B
MoA: Adrenergic receptor antagonist
SMILES: COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
InchiKey: BLGXFZZNTVWLAY-SCYLSFHTSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
7310 BRD-K35586044 HA1E 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.39
8810 BRD-K35586044 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.03 0.63
91023 BRD-K35586044 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99876 BRD-K35586044 U2OS 15 uM 6 h 0.23 0.97 0.08 0.21 0.75 0.04
120572 BRD-K35586044 A549 0.04 uM 24 h 0.27 1.13 0.28 0.0 0.0 0.0
120677 BRD-K35586044 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120730 BRD-K35586044 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120788 BRD-K35586044 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120838 BRD-K35586044 YAPC 1.11 uM 24 h 0.2 0.85 0.0 0.0 0.0 0.0
128992 BRD-K35586044 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129040 BRD-K35586044 HELA 0.01 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
129065 BRD-K35586044 MCF??7.00 0.08 uM 24 h -0.27 -1.13 0.41 -0.33 -1.11 0.92
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).