CMap Candidate Details
Structure:
CMap ID: | C13677 |
Pert ID: | BRD-K35586044 |
Compound Name: | yohimbine |
Targets: | ADRA2A; ADRA2B; ADRA2C; HTR1A; HTR1B; HTR1D; HTR2B |
MoA: | Adrenergic receptor antagonist |
SMILES: | COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |
InchiKey: | BLGXFZZNTVWLAY-SCYLSFHTSA-N |
Compound Aliases: | -- |
Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
---|---|---|---|---|---|---|---|---|---|---|
7310 | BRD-K35586044 | HA1E | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.28 | 0.99 | 0.39 |
8810 | BRD-K35586044 | VCAP | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | -0.31 | -1.03 | 0.63 |
91023 | BRD-K35586044 | HUH7 | 10 uM | 72 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
99876 | BRD-K35586044 | U2OS | 15 uM | 6 h | 0.23 | 0.97 | 0.08 | 0.21 | 0.75 | 0.04 |
120572 | BRD-K35586044 | A549 | 0.04 uM | 24 h | 0.27 | 1.13 | 0.28 | 0.0 | 0.0 | 0.0 |
120677 | BRD-K35586044 | HT29 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
120730 | BRD-K35586044 | JURKAT | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
120788 | BRD-K35586044 | PC3 | 1.11 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
120838 | BRD-K35586044 | YAPC | 1.11 uM | 24 h | 0.2 | 0.85 | 0.0 | 0.0 | 0.0 | 0.0 |
128992 | BRD-K35586044 | A375 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
129040 | BRD-K35586044 | HELA | 0.01 uM | 3 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
129065 | BRD-K35586044 | MCF??7.00 | 0.08 uM | 24 h | -0.27 | -1.13 | 0.41 | -0.33 | -1.11 | 0.92 |