CMap Candidate Details

Structure:
CMap ID: C13714
Pert ID: BRD-K35708212
Compound Name: ouabain
Targets: ATP1A1
MoA: ATPase inhibitor
SMILES: C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O
InchiKey: LPMXVESGRSUGHW-CIMHIGIKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4218 BRD-K35708212 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4565 BRD-K35708212 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4800 BRD-K35708212 PC3 10 uM 6 h 0.0 0.0 0.0 -0.5 -1.68 15.65
39125 BRD-K35708212 A375 10 uM 6 h 0.0 0.0 0.0 -0.47 -1.59 15.65
39319 BRD-K35708212 A549 10 uM 24 h 0.0 0.0 0.0 -0.55 -1.84 15.65
39681 BRD-K35708212 ASC 10 uM 24 h 0.27 1.11 0.25 -0.24 -0.82 0.15
39994 BRD-K35708212 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.5 -1.69 15.65
40266 BRD-K35708212 HT29 10 uM 6 h -0.21 -0.89 0.03 0.0 0.0 0.0
40615 BRD-K35708212 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.4 -1.33 1.83
40800 BRD-K35708212 NEU 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.4
41103 BRD-K35708212 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41436 BRD-K35708212 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
88549 BRD-K35708212 VCAP 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96056 BRD-K35708212 PHH 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99878 BRD-K35708212 U2OS 2.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).