CMap Candidate Details

Structure:
CMap ID: C13721
Pert ID: BRD-K35719256
Compound Name: rotundine
Targets: DRD1; DRD2; DRD3; HTR1A
MoA: Serotonin receptor agonist
SMILES: COc1cc2CCN3Cc4c(C[C@H]3c2cc1OC)ccc(OC)c4OC
InchiKey: AEQDJSLRWYMAQI-KRWDZBQOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
120574 BRD-K35719256 A549 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120679 BRD-K35719256 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
120732 BRD-K35719256 JURKAT 1.11 uM 24 h -0.37 -1.54 1.43 0.0 0.0 0.0
120789 BRD-K35719256 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120840 BRD-K35719256 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.6
128994 BRD-K35719256 A375 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129011 BRD-K35719256 HA1E 0.03 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
129041 BRD-K35719256 HELA 0.01 uM 3 h 0.0 0.0 0.0 -0.29 -0.97 0.45
129067 BRD-K35719256 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
136450 BRD-K35719256 SHSY5Y 0.37 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).