CMap Candidate Details

Structure:
CMap ID: C13737
Pert ID: BRD-K35781423
Compound Name: SANT-2
Targets: SHH; SMO
MoA: Smoothened receptor antagonist
SMILES: CCOc1cc(cc(OCC)c1OCC)C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccccc2[nH]1
InchiKey: VQOJFGFKIVFMDH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90594 BRD-K35781423 HCT116 3.33 uM 24 h 0.0 0.0 0.0 -0.43 -1.46 15.35
90684 BRD-K35781423 MCF10A 10 uM 24 h 0.29 1.2 0.43 -0.35 -1.17 1.12
96600 BRD-K35781423 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96672 BRD-K35781423 PC3 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.12
97984 BRD-K35781423 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98017 BRD-K35781423 MCF??7.00 10 uM 24 h 0.2 0.85 0.01 -0.41 -1.38 2.02
98059 BRD-K35781423 P1A82 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).