CMap Candidate Details

Structure:
CMap ID: C13787
Pert ID: BRD-K35941380
Compound Name: methysergide
Targets: HTR1B; HTR1E; HTR1F; HTR2A; HTR2B; HTR2C; HTR7
MoA: Serotonin receptor antagonist
SMILES: CC[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3cn(C)c4cccc(C2=C1)c34
InchiKey: KPJZHOPZRAFDTN-ZRGWGRIASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5320 BRD-K35941380 HA1E 10 uM 24 h -0.28 -1.18 0.51 0.27 0.96 0.34
5614 BRD-K35941380 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.13
6020 BRD-K35941380 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6089 BRD-K35941380 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.28
6181 BRD-K35941380 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6388 BRD-K35941380 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37146 BRD-K35941380 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37283 BRD-K35941380 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37642 BRD-K35941380 ASC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
37896 BRD-K35941380 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.34 1.21 1.15
38468 BRD-K35941380 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38944 BRD-K35941380 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91481 BRD-K35941380 HUH7 10 uM 72 h 0.19 0.79 0.0 0.0 0.0 0.0
99879 BRD-K35941380 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).