CMap Candidate Details

Structure:
CMap ID: C13796
Pert ID: BRD-K35960502
Compound Name: niclosamide
Targets: STAT3
MoA: STAT inhibitor; DNA replication inhibitor
SMILES: Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O
InchiKey: RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5904 BRD-K35960502 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6021 BRD-K35960502 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6090 BRD-K35960502 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.41 -1.37 2.02
6538 BRD-K35960502 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9414 BRD-K35960502 AGS 10 uM 6 h -0.23 -0.96 0.09 0.0 0.0 0.0
9722 BRD-K35960502 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10276 BRD-K35960502 HCC515 10 uM 6 h -0.2 -0.85 0.01 -0.39 -1.31 1.69
10508 BRD-K35960502 HCT116 10 uM 6 h 0.0 0.0 0.0 -0.54 -1.82 15.65
11477 BRD-K35960502 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12041 BRD-K35960502 NCIH596 10 uM 6 h 0.0 0.0 0.0 -0.45 -1.5 15.35
12307 BRD-K35960502 NOMO1 10 uM 6 h 0.0 0.0 0.0 -0.39 -1.32 1.71
12972 BRD-K35960502 THP1 10 uM 6 h 0.26 1.08 0.21 0.0 0.0 0.0
13264 BRD-K35960502 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44574 BRD-K35960502 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44937 BRD-K35960502 ASC 10 uM 24 h -0.24 -1.0 0.15 -0.27 -0.9 0.28
46057 BRD-K35960502 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46373 BRD-K35960502 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46692 BRD-K35960502 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97714 BRD-K35960502 NKDBA 0.37 uM 24 h -0.18 -0.76 0.0 -0.34 -1.13 0.98
99030 BRD-K35960502 NEU 10 uM 6 h -0.27 -1.12 0.38 -0.42 -1.41 2.02
99880 BRD-K35960502 U2OS 10 uM 6 h 0.24 1.0 0.11 -0.31 -1.05 0.69
121861 BRD-K35960502 YAPC 1.11 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.09
129745 BRD-K35960502 A375 0.25 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.15
129777 BRD-K35960502 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
129808 BRD-K35960502 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129863 BRD-K35960502 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
129934 BRD-K35960502 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
130019 BRD-K35960502 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130073 BRD-K35960502 PC3 0.74 uM 24 h 0.23 0.96 0.07 -0.32 -1.08 0.81
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).