CMap Candidate Details

Structure:
CMap ID: C01389
Pert ID: BRD-A58048407
Compound Name: nimodipine
Targets: NR3C2; CACNA1C; CACNA1D; CACNA1F; CACNA1S
MoA: Calcium channel blocker
SMILES: COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C
InchiKey: UIAGMCDKSXEBJQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5268 BRD-A58048407 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.3
9147 BRD-A58048407 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9296 BRD-A58048407 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9599 BRD-A58048407 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10348 BRD-A58048407 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10407 BRD-A58048407 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10674 BRD-A58048407 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11347 BRD-A58048407 NCIH2073 10 uM 6 h -0.23 -0.96 0.1 -0.23 -0.79 0.1
11660 BRD-A58048407 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12210 BRD-A58048407 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12672 BRD-A58048407 SW480 10 uM 6 h -0.23 -0.94 0.08 0.0 0.0 0.0
13155 BRD-A58048407 U937 10 uM 6 h 0.0 0.0 0.0 0.25 0.87 0.17
13426 BRD-A58048407 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37088 BRD-A58048407 A375 10 uM 6 h 0.31 1.28 0.6 0.0 0.0 0.0
37524 BRD-A58048407 ASC 10 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
38650 BRD-A58048407 PHH 10 uM 24 h 0.22 0.93 0.05 0.21 0.75 0.04
38875 BRD-A58048407 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52244 BRD-A58048407 PC3 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
91035 BRD-A58048407 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
98733 BRD-A58048407 NPC 10 uM 24 h 0.0 0.0 0.0 0.21 0.74 0.04
98843 BRD-A58048407 NEU 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.2
100239 BRD-A58048407 U2OS 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123900 BRD-A58048407 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123965 BRD-A58048407 HT29 0.37 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
124001 BRD-A58048407 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124054 BRD-A58048407 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124124 BRD-A58048407 MDAMB231 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.53
124183 BRD-A58048407 THP1 3.33 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.12
124235 BRD-A58048407 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132196 BRD-A58048407 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132253 BRD-A58048407 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).