CMap Candidate Details

Structure:
CMap ID: C13927
Pert ID: BRD-K36280065
Compound Name: tofacitinib
Targets: JAK1; JAK2; JAK3
MoA: JAK inhibitor
SMILES: C[C@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N
InchiKey: UJLAWZDWDVHWOW-AAEUAGOBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
87328 BRD-K36280065 BJAB 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.47
87366 BRD-K36280065 HBL1 0.01 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
87416 BRD-K36280065 K562 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
87464 BRD-K36280065 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87527 BRD-K36280065 MINO 10 uM 6 h -0.27 -1.13 0.41 0.27 0.95 0.31
87568 BRD-K36280065 NALM6 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87618 BRD-K36280065 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.34 1.2 1.13
87669 BRD-K36280065 OCILY19 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.32
87720 BRD-K36280065 OCILY3 2.5 uM 24 h 0.24 1.0 0.1 0.33 1.16 0.9
87767 BRD-K36280065 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87790 BRD-K36280065 THP1 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87853 BRD-K36280065 TMD8 10 uM 3 h -0.22 -0.91 0.05 0.0 0.0 0.0
90895 BRD-K36280065 MCF10A 3.33 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95406 BRD-K36280065 U2OS 10 uM 24 h -0.18 -0.76 0.0 0.3 1.06 0.58
120581 BRD-K36280065 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120610 BRD-K36280065 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120631 BRD-K36280065 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.38 1.34 1.72
120686 BRD-K36280065 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120740 BRD-K36280065 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120762 BRD-K36280065 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
120793 BRD-K36280065 PC3 1.11 uM 24 h 0.0 0.0 0.0 0.37 1.33 1.71
120848 BRD-K36280065 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
128999 BRD-K36280065 A375 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).