CMap Candidate Details

Structure:
CMap ID: C01393
Pert ID: BRD-A58280226
Compound Name: Y-27632
Targets: ROCK1; ROCK2
MoA: Rho associated kinase inhibitor
SMILES: CC(N)C1CCC(CC1)C(=O)Nc2ccncc2
InchiKey: IYOZTVGMEWJPKR-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9600 BRD-A58280226 H1299 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10248 BRD-A58280226 HCC515 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10675 BRD-A58280226 HEPG2 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11348 BRD-A58280226 NCIH2073 4 uM 6 h 0.0 0.0 0.0 0.31 1.1 0.7
11661 BRD-A58280226 NCIH508 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11920 BRD-A58280226 NCIH596 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12211 BRD-A58280226 NOMO1 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12673 BRD-A58280226 SW480 4 uM 6 h 0.36 1.49 1.12 0.0 0.0 0.0
13156 BRD-A58280226 U937 4 uM 6 h 0.0 0.0 0.0 0.28 1.01 0.43
13539 BRD-A58280226 VCAP 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91789 BRD-A58280226 HS578T 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91925 BRD-A58280226 SKBR3 10 uM 24 h 0.19 0.81 0.0 0.0 0.0 0.0
93664 BRD-A58280226 ASC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93727 BRD-A58280226 CD34 0.12 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
93852 BRD-A58280226 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.8
93995 BRD-A58280226 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
94037 BRD-A58280226 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94117 BRD-A58280226 NEU 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94161 BRD-A58280226 NPC 0.12 uM 24 h 0.28 1.18 0.4 -0.39 -1.3 1.6
94251 BRD-A58280226 SHSY5Y 0.37 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.11
94302 BRD-A58280226 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95360 BRD-A58280226 MCF??7.00 10 uM 48 h 0.21 0.89 0.02 0.0 0.0 0.0
95451 BRD-A58280226 U2OS 10 uM 6 h 0.2 0.83 0.0 0.0 0.0 0.0
124307 BRD-A58280226 HA1E 3.33 uM 24 h 0.0 0.0 0.0 -0.41 -1.37 2.02
124392 BRD-A58280226 HT29 10 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
124527 BRD-A58280226 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124558 BRD-A58280226 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132339 BRD-A58280226 A375 0.74 uM 24 h 0.22 0.94 0.05 0.32 1.14 0.85
132369 BRD-A58280226 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132449 BRD-A58280226 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
132506 BRD-A58280226 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132562 BRD-A58280226 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.51
132622 BRD-A58280226 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).